The functions of long non-coding RNAs in neural stem cell proliferation and differentiation

Cell & Bioscience

Table 3 The major roles of lncRNAs in neurodevelopmental disorders

LncRNA name	Mechanism	Biological function	Disease	References
TUNA	Interact with RBPs	Promote neural differentiation	HD	[71]
FMR4	Derived from FMR1 locus	Promote hNPCs proliferation	Fragile X syndrome	[77]
RPS10P2-AS1	Interact with RPS10P2		ASD	[78]
MSNP1AS	Regulate chromatin organization and immune response related gene	Inhibit neural differentiation	ASD	[72, 79]
C21orf121	miR-140-5p/BMP2	Promote neurogenesis	ASD	[80]
H19	p53/Notch1 pathway	Block neurogenesis	Ischemic stroke	[74]
Meg3	Notch or Wnt/β-catenin signaling pathway, miR-128-3p/ATRA/cAMP/CREB axis	Promote neurogenesis/neural differentiation	Ischemia-reperfusion injury	[75, 82]
NEAT1	Associated with Wnt signaling	Promote oligodendrogenesis	Schizophrenia	[94]
HOTAIR	miR-136-5p/AKT2-NF-κB		Demyelination	[95]

ISSN: 2045-3701