Table 2 The roles of lncRNAs on NSCs differentiation/neurogenesis and oligodendrogenesis

Sox2ot

Link with Sox2, interact with YY1

Prohibit NSCs proliferation and advance neuronal differentiation

[54]

RMST

Target Sox2

Promote neurogenesis

[56]

Kdm2b

Bind with hnRNPAB and activate Kdm2b gene expression

Promote neurogenesis

[57]

Paupar

Bind with local genes-Pax6 and KAP1

Promote neurogenesis

[58, 59]

Gm21284

Interact with miR-30e-3p, miR-431 and miR-147

Inhibit NSCs proliferation while promote NSCs differentiation

[63]

1604

miR-200c/ZEB1/2 axis

Promote neural differentiation

[61]

Rik-201

Activated by C/EBPβ, miR-96/Sox6

Enhance neural differentiation

[64]

Rik-203

miR-467a-3p/Sox6, miR-101-3a/GSK-3β

Enhance neural differentiation

[64, 65]

Malat1

Activate ERK/MAPK, inhibit PPAR/p53

Promote neural differentiation

[67]

Pnky

Interact with PTBP1

Inhibit neural differentiation and neurogenesis

[3, 68]

lncR492

Interact with HuR and activate Wnt signalling

Inhibit neural differentiation

[69]

BDNF-AS

Targeting TrkB signaling pathway

Inhibit eNSCs-derived neurite outgrowth

[70]

UCA1

miR-1/Hes1

Promote NSCs differentiation to astrocyte but neuron

[48]

OPC

Regulated by OLIG2

Promote oligodendrogenesis

[87]

lncOL1

Form a complex with Suz12

Promote oligodendrogenesis

[90]

lnc158

Promote NFIB expression

Promote oligodendrogenesis

[91]

Pcdh17it

Oligodendrogenesis marker

[92]

OLMALIN/-AS

Regulate oligodendrocyte maturation

[93]