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Fig. 10 | Cell & Bioscience

Fig. 10

From: Ghrelin, a novel therapy, corrects cytokine and NF-κB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma

Fig. 10

Ghrelin therapy increases tight junction protein in ileum and mitigates bacterial translocation and lipopolysaccharides (LPS) levels. a Animals were irradiated alone or irradiated followed by wounding. Ileum lysate samples collected on day 7 were used to detect claudin 2, a biomarker for the tight junction (N = 4 per group). b The liver lysate samples (100 mg per sample) from each animal (N = 6) were used for measuring bacterial DNA, presented as ng/g liver. c The liver lysate samples from each animal (N = 6) were used for measuring LPS levels using the LPS ELISA Kit, presented as O.D./µg protein. The data presented are mean ± sem. *p < 0.05 vs. RI + VEH. W wounding; RI: 9.5 Gy; CI: 9.5 Gy + wounding; VEH vehicle, GHR Ghrelin

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Cell & Bioscience

ISSN: 2045-3701

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