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Table 1 miRNAs expression patterns in human oral diseases

From: Emerging functions and clinical applications of exosomes in human oral diseases

Diseases Source Exosomal miRNAs Amounts Effects of exosomal miRNAs References
Oral squamous cell carcinoma Hypoxic SCC-9 and CAL-27 miR-21 Up CAL-27-derived exosomes was maily used in functinal experiments.Exosomal miR-21 induced prometastatic behaviors under hypoxia condition [20]
cisplatin-resistant HSC-3 and SCC-9 miR-21 Up exosomes transferred miR-21 to OSCC parental cells and induced cisplatin resistance [18]
HOC313-LM miR-1246, miR-342–3p Up Increased the migration and invasion ability of HOC313-P cells. exosomal miR-1246 enhanced cell motility [19]
SCC-9, CAL-27 miR-29a-3p up promoted M2-subtype macrophages polarization via SOCS1/STAT6 signaling pathway [21]
Primary cancer-associated fibroblasts miR-34a-5p Down miR-34a-5p/AXL axis promoted OSCC progression, inducing the EMT to promote cancer cells metastasis [53]
Saliva miR-412-3p, miR-512-3p, miR-27a-3p, miR-373-3p and miR-494-3p, miR-302b-3p, miR-517b-3p Up Potentially be used in liquid biopsy; miR-302b-3p, miR-517b-3p expressed specifically only in samples from OSCC saliva [59]
Serum miR-21   Closely associated with HIF-1a/HIF-2a expression, T stage, and lymph node metastasis [20]
Plasma hsa-miR-19a, hsa-miR-512-3p, hsa-miR-27b, hsa-miR-20a, hsa-miR-28-3p, hsa-miR-200c, hsa-miR-223, hsa-miR-20b, hsa-miR-151-3p Up More reliable for evaluation of circulating tumor-miRNA expression than plasma [63]
hsa-miR-22, hsa-miR-370, hsa-miR-139-5p, hsa-let-7e, hsa-miR-145-3p, hsa-miR-30c Down
Primary Sjögren’s syndrome EBV-infected B cells ebv-miR-BART13-3p Not shown Decreased store operated Ca2+ entry and Ca2+-dependent activation of NFAT in SGECs [89]
Oral lichen planus Saliva miR-4484 Up Potential miRNA biomarker for OLP [93]
Plasma miR-34a-5p, miR-130b-3p Up miR-34a-5p was positively correlated with the severity of OLP [22]
miR-301b-3p Down Not shown
Hand, foot and mouth disease Serum miR-16-5p Up Biomarkers for diagnose, and miR-671-5p may be used for subtyping HFMD [98]
miR-671-5p, miR-150-5p Down
Oral leukoplakia MSCs from human primary tissues miR-8485 Up Promoted the proliferation, migration and invasion of DOK and SCC-15 cell lines [68]
Murine bone marrow-MSCs miR-185 Up* Attenuated inflammation severity and decreased degree of dysplasia in the OPMD tissue [69]
Periodontitis LPS-stimulated periodontal ligament stem cells miR‐155 Up Reducing the expression of Th17 and increasing the expression of Treg [79]
  1. Up: the expression of miRNAs was upregulated in exosomes
  2. Up*: the the expression of miRNAs in exosomes was upregulated by transfection
  3. Down: the expression of miRNAs was down regulated in exosomes