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Table 1 miRNAs expression patterns in human oral diseases

From: Emerging functions and clinical applications of exosomes in human oral diseases

Diseases

Source

Exosomal miRNAs

Amounts

Effects of exosomal miRNAs

References

Oral squamous cell carcinoma

Hypoxic SCC-9 and CAL-27

miR-21

Up

CAL-27-derived exosomes was maily used in functinal experiments.Exosomal miR-21 induced prometastatic behaviors under hypoxia condition

[20]

cisplatin-resistant HSC-3 and SCC-9

miR-21

Up

exosomes transferred miR-21 to OSCC parental cells and induced cisplatin resistance

[18]

HOC313-LM

miR-1246, miR-342–3p

Up

Increased the migration and invasion ability of HOC313-P cells. exosomal miR-1246 enhanced cell motility

[19]

SCC-9, CAL-27

miR-29a-3p

up

promoted M2-subtype macrophages polarization via SOCS1/STAT6 signaling pathway

[21]

Primary cancer-associated fibroblasts

miR-34a-5p

Down

miR-34a-5p/AXL axis promoted OSCC progression, inducing the EMT to promote cancer cells metastasis

[53]

Saliva

miR-412-3p, miR-512-3p, miR-27a-3p, miR-373-3p and miR-494-3p, miR-302b-3p, miR-517b-3p

Up

Potentially be used in liquid biopsy; miR-302b-3p, miR-517b-3p expressed specifically only in samples from OSCC saliva

[59]

Serum

miR-21

 

Closely associated with HIF-1a/HIF-2a expression, T stage, and lymph node metastasis

[20]

Plasma

hsa-miR-19a, hsa-miR-512-3p, hsa-miR-27b, hsa-miR-20a, hsa-miR-28-3p, hsa-miR-200c, hsa-miR-223, hsa-miR-20b, hsa-miR-151-3p

Up

More reliable for evaluation of circulating tumor-miRNA expression than plasma

[63]

hsa-miR-22, hsa-miR-370, hsa-miR-139-5p, hsa-let-7e, hsa-miR-145-3p, hsa-miR-30c

Down

Primary Sjögren’s syndrome

EBV-infected B cells

ebv-miR-BART13-3p

Not shown

Decreased store operated Ca2+ entry and Ca2+-dependent activation of NFAT in SGECs

[89]

Oral lichen planus

Saliva

miR-4484

Up

Potential miRNA biomarker for OLP

[93]

Plasma

miR-34a-5p, miR-130b-3p

Up

miR-34a-5p was positively correlated with the severity of OLP

[22]

miR-301b-3p

Down

Not shown

Hand, foot and mouth disease

Serum

miR-16-5p

Up

Biomarkers for diagnose, and miR-671-5p may be used for subtyping HFMD

[98]

miR-671-5p, miR-150-5p

Down

Oral leukoplakia

MSCs from human primary tissues

miR-8485

Up

Promoted the proliferation, migration and invasion of DOK and SCC-15 cell lines

[68]

Murine bone marrow-MSCs

miR-185

Up*

Attenuated inflammation severity and decreased degree of dysplasia in the OPMD tissue

[69]

Periodontitis

LPS-stimulated periodontal ligament stem cells

miR‐155

Up

Reducing the expression of Th17 and increasing the expression of Treg

[79]

  1. Up: the expression of miRNAs was upregulated in exosomes
  2. Up*: the the expression of miRNAs in exosomes was upregulated by transfection
  3. Down: the expression of miRNAs was down regulated in exosomes