Skip to main content
Fig. 4 | Cell & Bioscience

Fig. 4

From: Direct activation of tRNA methyltransferase-like 1 (Mettl1) gene by thyroid hormone receptor implicates a role in adult intestinal stem cell development and proliferation during Xenopus tropicalis metamorphosis

Fig. 4

TR binds to the TRE in the Mettl1 promoter region in the intestine during T3-induced metamorphosis. ChIP assays were performed with indicated antibodies on the intestine of premetamorphic tadpoles treated with or with T3. a Liganded TR is present in the TRE region of Mettl1 promoter in the intestine of premetamorphic tadpoles and the binding is increased by T3 treatment. b The level of di-methylated H3K79, a histone mark for transcription activation, increases in the TRE region after T3 treatment. c RNA polymerase II is recruited to the Mettl1 TRE region after T3 treatment. d Only background ChIP signal is detected with the negative control IgG ChIP in the presence or absence of T3 treatment. All data represent mean ± S.E.M. Significance value was ***P ≤ 0.005. n.s. not significant

Back to article page

Cell & Bioscience

ISSN: 2045-3701

Contact us