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Table 2 35 differential expressed metabolites in p53-wt vs.p53-KO HBE cells post 4 Gy radiation

From: Integrated analysis of transcriptomic and metabolomic profiling reveal the p53 associated pathways underlying the response to ionizing radiation in HBE cells

MetabolitesVIP*log2 (FC)p-valueClassSub class
Erythronic acid lactone1.069220.61586.9E−05LactonesOrganoheterocyclic compounds
Hydroxylamine1.349410.197980.04045Homogeneous other non-metal compoundsHomogeneous non-metal compounds
4-hydroxymandelic acid1.36889− 0.69960.00142PhenolsBenzenoids
Erythronic acid1.42277− 1.70930.00929Organooxygen compoundsOrganic oxygen compounds
Epsilon-caprolactam1.34602− 0.71270.00061LactamsOrganoheterocyclic compounds
Allothreonine1.46924− 0.50490.00792Carboxylic acids and derivativesOrganic acids and derivatives
Metharbital1.41033− 1.03010.00381DiazinesOrganoheterocyclic compounds
Nicotinic acid1.42734− 0.52830.00083Pyridines and derivativesOrganoheterocyclic compounds
3,3-dimethyl-1-hydroxy-cyclohexene1.009− 1.30950.00151
Cyanoalanine1.40793− 0.74559.4E−05
2,4-diaminobutyric acid1.4873− 0.7930.03173Carboxylic acids and derivativesOrganic acids and derivatives
Isocitric acid1.43121− 1.32290.01103Carboxylic acids and derivativesOrganic acids and derivatives
Alpha-tocopherol1.47328− 1.07290.00435Prenol lipidsLipids and lipid-like molecules
Arbutin1.06715− 1.28650.00725Organooxygen compoundsOrganic oxygen compounds
5-hydroxymethyl-2-furoic acid1.38372− 2.00630.00456FuransOrganoheterocyclic compounds
Alloxanoic acid1.15251− 2.2650.0279
3-hydroxybenzoic acid1.4286− 1.470.00704Benzene and substituted derivativesBenzenoids
4-hydroxyphenylacetic acid1.34886− 0.71950.01778Phenol estersBenzenoids
Succinylacetone1.00743− 3.63890.01924Keto acids and derivativesOrganic acids and derivatives
Chlorogenic acid1.01029− 2.13080.00706Organooxygen compoundsOrganic oxygen compounds
Tocopherol acetate1.3993− 1.86710.01908Prenol lipidsLipids and lipid-like molecules
Pseudo uridine1.24524− 0.41210.03491Nucleoside and nucleotide analoguesNucleosides, nucleotides, and analogues
Epicatechin1.37918− 0.92620.01609FlavonoidsPhenylpropanoids and polyketides
O-phosphoethanolamine1.376530.871160.04621Organic phosphoric acids and derivativesOrganic acids and derivatives
Azelaic acid1.13179− 1.31060.00278Fatty AcylsLipids and lipid-like molecules
Beta-glutamic acid1.22441− 0.45230.03566
Lactobionic acid1.34112− 1.07720.01633
Arsenate1.03192− 1.91820.00398Miscellaneous mixed metal/non-metalsMixed metal/non-metal compounds
Palatinitol1.27221− 0.70680.0263
L-allothreonine1.38117− 0.68690.04396Purine nucleosidesNucleosides, nucleotides, and analogues
Oleamide1.022860.28530.01158Fatty AcylsLipids and lipid-like molecules
1,3-diphosphoglycerol1.129541.409690.02935
D-erythro-sphingosine1.24636− 0.56130.02118Organonitrogen compoundsOrganic nitrogen compounds
Phytosphingosine1.11889− 0.69930.0023Organonitrogen compoundsOrganic nitrogen compounds
  1. A positive value indicates up regulation and a negative value indicates down regulation
  2. * Vip variable important in projection, The larger the VIP, the greater the contribution of this variable to the grouping; log2 (FC): the ratio of the average expression amount of metabolites in the two groups of samples