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Table 2 35 differential expressed metabolites in p53-wt vs.p53-KO HBE cells post 4 Gy radiation

From: Integrated analysis of transcriptomic and metabolomic profiling reveal the p53 associated pathways underlying the response to ionizing radiation in HBE cells

Metabolites

VIP*

log2 (FC)

p-value

Class

Sub class

Erythronic acid lactone

1.06922

0.6158

6.9E−05

Lactones

Organoheterocyclic compounds

Hydroxylamine

1.34941

0.19798

0.04045

Homogeneous other non-metal compounds

Homogeneous non-metal compounds

4-hydroxymandelic acid

1.36889

− 0.6996

0.00142

Phenols

Benzenoids

Erythronic acid

1.42277

− 1.7093

0.00929

Organooxygen compounds

Organic oxygen compounds

Epsilon-caprolactam

1.34602

− 0.7127

0.00061

Lactams

Organoheterocyclic compounds

Allothreonine

1.46924

− 0.5049

0.00792

Carboxylic acids and derivatives

Organic acids and derivatives

Metharbital

1.41033

− 1.0301

0.00381

Diazines

Organoheterocyclic compounds

Nicotinic acid

1.42734

− 0.5283

0.00083

Pyridines and derivatives

Organoheterocyclic compounds

3,3-dimethyl-1-hydroxy-cyclohexene

1.009

− 1.3095

0.00151

–

–

Cyanoalanine

1.40793

− 0.7455

9.4E−05

–

–

2,4-diaminobutyric acid

1.4873

− 0.793

0.03173

Carboxylic acids and derivatives

Organic acids and derivatives

Isocitric acid

1.43121

− 1.3229

0.01103

Carboxylic acids and derivatives

Organic acids and derivatives

Alpha-tocopherol

1.47328

− 1.0729

0.00435

Prenol lipids

Lipids and lipid-like molecules

Arbutin

1.06715

− 1.2865

0.00725

Organooxygen compounds

Organic oxygen compounds

5-hydroxymethyl-2-furoic acid

1.38372

− 2.0063

0.00456

Furans

Organoheterocyclic compounds

Alloxanoic acid

1.15251

− 2.265

0.0279

–

–

3-hydroxybenzoic acid

1.4286

− 1.47

0.00704

Benzene and substituted derivatives

Benzenoids

4-hydroxyphenylacetic acid

1.34886

− 0.7195

0.01778

Phenol esters

Benzenoids

Succinylacetone

1.00743

− 3.6389

0.01924

Keto acids and derivatives

Organic acids and derivatives

Chlorogenic acid

1.01029

− 2.1308

0.00706

Organooxygen compounds

Organic oxygen compounds

Tocopherol acetate

1.3993

− 1.8671

0.01908

Prenol lipids

Lipids and lipid-like molecules

Pseudo uridine

1.24524

− 0.4121

0.03491

Nucleoside and nucleotide analogues

Nucleosides, nucleotides, and analogues

Epicatechin

1.37918

− 0.9262

0.01609

Flavonoids

Phenylpropanoids and polyketides

O-phosphoethanolamine

1.37653

0.87116

0.04621

Organic phosphoric acids and derivatives

Organic acids and derivatives

Azelaic acid

1.13179

− 1.3106

0.00278

Fatty Acyls

Lipids and lipid-like molecules

Beta-glutamic acid

1.22441

− 0.4523

0.03566

–

–

Lactobionic acid

1.34112

− 1.0772

0.01633

–

–

Arsenate

1.03192

− 1.9182

0.00398

Miscellaneous mixed metal/non-metals

Mixed metal/non-metal compounds

Palatinitol

1.27221

− 0.7068

0.0263

–

–

L-allothreonine

1.38117

− 0.6869

0.04396

Purine nucleosides

Nucleosides, nucleotides, and analogues

Oleamide

1.02286

0.2853

0.01158

Fatty Acyls

Lipids and lipid-like molecules

1,3-diphosphoglycerol

1.12954

1.40969

0.02935

–

–

D-erythro-sphingosine

1.24636

− 0.5613

0.02118

Organonitrogen compounds

Organic nitrogen compounds

Phytosphingosine

1.11889

− 0.6993

0.0023

Organonitrogen compounds

Organic nitrogen compounds

  1. A positive value indicates up regulation and a negative value indicates down regulation
  2. * Vip variable important in projection, The larger the VIP, the greater the contribution of this variable to the grouping; log2 (FC): the ratio of the average expression amount of metabolites in the two groups of samples
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Cell & Bioscience

ISSN: 2045-3701

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