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Table 1 Top 20 differential expressed genes/mRNAs in the p53-wt vs. p53-KO HBE cells post 4 Gy radiation

From: Integrated analysis of transcriptomic and metabolomic profiling reveal the p53 associated pathways underlying the response to ionizing radiation in HBE cells

Upregulated mRNADownregulated mRNA
Gene-IDFold changelog2 (fold)p valueGene-IDFold changelog2 (fold)p value
DEFA678.339136.2916611.38E−11C8orf860.130736− 2.935270.009803
SLC3A120.163324.3336610.003823LOC1122680130.216001− 2.210890.00971
SCN1A19.798194.3072970.004904MATK0.217973− 2.197780.006171
ENTHD116.451924.0401840.013362TMEM56-RWDD30.252377− 1.986350.039409
RSPH6A13.8273.7894160.001236SCT0.256374− 1.963680.023869
CHRNA612.51583.6456790.045863P2RY40.267326− 1.903330.014581
SLC25A610.657123.4137460.011851LCN20.303939− 1.718155.85E−15
FAM163B9.6994093.2778977.21E−07SPRR2D0.306724− 1.704993.68E−13
TAS1R39.3041033.2178670.000423SLC26A40.316586− 1.659334.28E−25
RXFP48.3497563.0617340.005335POTEI0.318255− 1.651740.02425
MANSC47.4348272.8942990.011991STK32A0.325094− 1.621071.93E−17
GPR847.1724442.8424650.003795GPR390.326626− 1.614292.71E − 05
U2AF16.9063922.7879320.00111CD690.336596− 1.570910.003493
FAM19A36.6282522.7286280.026354LPAR60.338796− 1.561511.84E −07
CES5A6.4423182.687580.010618NT5E0.353169− 1.501572.36E−46
KCNJ26.2953742.6542920.026678FLNC0.355741− 1.49111.45E−15
SNCB6.0476672.5963790.044324INSC0.360171− 1.473250.021098
MAP2K65.470412.4516490.000226GZMB0.378744− 1.400714.97E−18
LHFPL15.3837892.4286220.000288LOC1027242190.389122− 1.36170.032583
DEFA678.339136.2916611.38E−11LGALS7B0.389833− 1.359070.002712
  1. p < 0.05 represents significantly changed