Table 1 Top 20 differential expressed genes/mRNAs in the p53-wt vs. p53-KO HBE cells post 4 Gy radiation
Upregulated mRNA | Downregulated mRNA | ||||||
|---|---|---|---|---|---|---|---|
Gene-ID | Fold change | log2 (fold) | p value | Gene-ID | Fold change | log2 (fold) | p value |
DEFA6 | 78.33913 | 6.291661 | 1.38E−11 | C8orf86 | 0.130736 | − 2.93527 | 0.009803 |
SLC3A1 | 20.16332 | 4.333661 | 0.003823 | LOC112268013 | 0.216001 | − 2.21089 | 0.00971 |
SCN1A | 19.79819 | 4.307297 | 0.004904 | MATK | 0.217973 | − 2.19778 | 0.006171 |
ENTHD1 | 16.45192 | 4.040184 | 0.013362 | TMEM56-RWDD3 | 0.252377 | − 1.98635 | 0.039409 |
RSPH6A | 13.827 | 3.789416 | 0.001236 | SCT | 0.256374 | − 1.96368 | 0.023869 |
CHRNA6 | 12.5158 | 3.645679 | 0.045863 | P2RY4 | 0.267326 | − 1.90333 | 0.014581 |
SLC25A6 | 10.65712 | 3.413746 | 0.011851 | LCN2 | 0.303939 | − 1.71815 | 5.85E−15 |
FAM163B | 9.699409 | 3.277897 | 7.21E−07 | SPRR2D | 0.306724 | − 1.70499 | 3.68E−13 |
TAS1R3 | 9.304103 | 3.217867 | 0.000423 | SLC26A4 | 0.316586 | − 1.65933 | 4.28E−25 |
RXFP4 | 8.349756 | 3.061734 | 0.005335 | POTEI | 0.318255 | − 1.65174 | 0.02425 |
MANSC4 | 7.434827 | 2.894299 | 0.011991 | STK32A | 0.325094 | − 1.62107 | 1.93E−17 |
GPR84 | 7.172444 | 2.842465 | 0.003795 | GPR39 | 0.326626 | − 1.61429 | 2.71E − 05 |
U2AF1 | 6.906392 | 2.787932 | 0.00111 | CD69 | 0.336596 | − 1.57091 | 0.003493 |
FAM19A3 | 6.628252 | 2.728628 | 0.026354 | LPAR6 | 0.338796 | − 1.56151 | 1.84E −07 |
CES5A | 6.442318 | 2.68758 | 0.010618 | NT5E | 0.353169 | − 1.50157 | 2.36E−46 |
KCNJ2 | 6.295374 | 2.654292 | 0.026678 | FLNC | 0.355741 | − 1.4911 | 1.45E−15 |
SNCB | 6.047667 | 2.596379 | 0.044324 | INSC | 0.360171 | − 1.47325 | 0.021098 |
MAP2K6 | 5.47041 | 2.451649 | 0.000226 | GZMB | 0.378744 | − 1.40071 | 4.97E−18 |
LHFPL1 | 5.383789 | 2.428622 | 0.000288 | LOC102724219 | 0.389122 | − 1.3617 | 0.032583 |
DEFA6 | 78.33913 | 6.291661 | 1.38E−11 | LGALS7B | 0.389833 | − 1.35907 | 0.002712 |