Fig. 1
From: A three layered histone epigenetics in breast cancer metastasis
Layers of histone epigenetics composed of histone chaperones, histone variants and their modifications. (1) First layer of histone epigenetics is histone chaperone, which recruits histone variants into the chromatin. Canonical histones are recruited in replication dependent manner while non-canonical histone variants are recruited in replication independent manner. (2) Second layer of histone epigenetics is histone variants, which plays an important role of maintaining chromatin switch [ON/OFF state]. (3) Final layer of histone epigenetics is Histone Modifications which further modifies the chromatin state by addition of functional groups into the tails of histones