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Fig. 7 | Cell & Bioscience

Fig. 7

From: Nonalcoholic fatty liver disease experiences accumulation of hepatic liquid crystal associated with increasing lipophagy

Fig. 7

Comparisons between optical properties of LD-HLD from NAFLD patients and HiF diet induced NAFLD mice. A LC-HLDs from patients (pLC-HLDs) display three types of birefringence, inner-non activity (INA) Maltese-cross birefringence, full birefringent activity (FBA) Maltese-cross birefringence, and crystalline birefringence (panel Aa, Ab and Ac). Optical activity of pLC-INA and pLC-FBA lipid droplets are similar to optical properties of INA and FBA LC-HLD from HiF diet induced NAFLD mouse livers (panel f and g). B Plate rotation demonstrates that the pattern of optical activity in pLC-INA is independent from rotation angle (α) ranging from 0° to 360° (panel a–i). Strong birefringence remains on the cortical edge of pLC-HLDs (arrows) regardless of the changing angle of polarized light (top in panel a, c, e, g and i, and bottom in panel b, d, f and h), indicating that optical activity is restricted to the cortex of a spherical droplet

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