Table 1 Summary of all Brca1 mutant alleles

Mice with complete disruption of BRCA1

 MGI:1858108

Brca1 <tm1Mak> 

Brca1^Δ5-6

Die before E7.5

[35]

 MGI:2429692

Brca1 <tm2Mak> 

Brca1^flox5-6

Conditional, viable

[38]

 MGI:3762184

Brca1 <tm1.1Brn> 

Brca1^Δ5-13

Embryonic lethal, embryonic development not analyzed

[39]

 MGI:3696057

Brca1 <tm1Brn> 

Brca1^flox5-13

Conditional, viable

[39]

Mice with Exon11 disruptions

 MGI:1857931

Brca1 <tm1Bhk> 

Brca1^Δ223-763

Die between E8.5 to E13.5

[40]

 MGI:1930612

Brca1 <tm1Cxd> 

Brca1¹¹⁻

Die between E7.5 and E9.5

[42]

 MGI:1858107

Brca1 <tm1Whl> 

Brca1^Δ300-361

Die before E7.5

[43]

 MGI:2177209

Brca1 <tm2Arge> 

Brca1^tr

Largely viable, viability depends on genetic background

[44]

 MGI:2182470

Brca1 <tm2.1Cxd> 

Brca1^Δ11

Seldomly viable, most die between E12.5–18.5

[45]

 MGI:1931238

Brca1 <tm2Cxd> 

Brca1^flox11

Conditional, viable

[45]

 MGI:3665173

Brca1 <tm4Cxd> 

Brca1^FL

Viable

[47]

Mice with RING domain disruptions

 MGI:1930613

Brca1 <tm1Arge> 

Brca1^ex2

Die between E6.5 and E9.5

[48]

 MGI:3790741

Brca1 <tm1Thl> 

Brca1^flex2

Conditional, viable

[49]

 MGI:5823771

Brca1 <tm2Jjon> 

Brca1^185stop

Die between E9.5 to E13.5

[50]

 MGI:5307254

Brca1 <tm1.1Jjon> 

Brca1^C61G

Die between E9.5 and E12.5

[51]

 MGI:5494435

Brca1 <tm3.1Thl> 

Brca1^I26A

Viable

[41]

Mice with BRCT domain disruptions

 MGI:2178447

Brca1 <tm1Rfo> 

Brca1^1700T

Die between E9.5 and E10.5

[53]

 MGI:5823772

Brca1 <tm3Jjon> 

Brca1^5382stop

Die between E9.5 and E12.5

[50]

 MGI:3706167

Brca1 <tm1Aash> 

Brca1^F22-24

Conditional, viable

[54]

 MGI:6281370

Brca1 <em1Njo> 

Brca1^ΔC

Embryonic lethal, embryonic development not analyzed

[56]

 MGI:5494434

Brca1 <tm2.1Thl> 

Brca1^S1598F

Viable

[41]

Mice with disrupted phosphorylation

 MGI:3513253

Brca1 <tm3Cxd> 

Brca1^S971A

Viable

[61]

 MGI:4418211

Brca1 <tm5.1Cxd> 

Brca1^S1152A

Viable

[62]