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Fig. 6 | Cell & Bioscience

Fig. 6

From: OTUB1-mediated deubiquitination of FOXM1 up-regulates ECT-2 to promote tumor progression in renal cell carcinoma

Fig. 6

OTUB1 knockdown inhibited in vivo RCC tumor growth. a Knockdown efficiency of Ad-shOTUB1 in nude mice as measured by qRT-PCR. ** represents Ad-shOTUB1 vs. Ad-shNC, p < 0.01. b The effect of Ad-shOTUB1 on RCC tumor growth and volume. ** represents Ad-shOTUB1 vs. Ad-shNC, p < 0.01. c The effect of Ad-shOTUB1 on proteins expression of OTUB1, FOXM1, ECT2, GTP-Rho and GTP-Rac1 in xenograft tumor mice. ** represents Ad-shOTUB1 vs. Ad-shNC, p < 0.01. d Immunohistochemistry analysis of OTUB1, FOXM1, ECT2 and Ki67 in tissues of mice intratumorally injected with Ad-shOTUB1 or Ad-shNC

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Cell & Bioscience

ISSN: 2045-3701

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