Fig. 5

Inhibition ability of OTUB1 knockdown on RCC progression was reversed by FOXM1 over-expression. a The effect of siOTUB1 and pcDNA 3.1-FOXM1 on protein expression levels of OTUB1 and FOXM1 in Caki-1 and 786-O cells. ** represents siOTUB1 vs. siNC or pcDNA 3.1-FOXM1 + siOTUB1 vs. siOTUB1 + pcDNA 3.1-NC, p < 0.01. b The effect of siOTUB1 and pcDNA 3.1-FOXM1 on cell proliferation of Caki-1 and 786-O cells. *, ** represents siOTUB1 vs. siNC or pcDNA 3.1-FOXM1 + siOTUB1 vs. siOTUB1 + pcDNA 3.1-NC, p < 0.05, p < 0.01. c The effect of siOTUB1 and pcDNA 3.1-FOXM1 on cell migration of Caki-1 and 786-O cells. *, ** represents siOTUB1 vs. siNC or pcDNA 3.1-FOXM1 + siOTUB1 vs. siOTUB1 + pcDNA 3.1-NC, p < 0.05, p < 0.01. d The effect of siOTUB1 and pcDNA 3.1-FOXM1 on cell invasion of Caki-1 and 786-O cells. ** represents siOTUB1 vs. siNC or pcDNA 3.1-FOXM1 + siOTUB1 vs. siOTUB1 + pcDNA 3.1-NC, p < 0.01