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Table 2 The fold change of cell proliferation in day 5 of each EGFR mutation compared to day 0 and IC50 value of erlotinib treatment in each EGFR mutations

From: HCC-derived EGFR mutants are functioning, EGF-dependent, and erlotinib-resistant

EGFR mutations

Fold change of cell proliferation

IC50 value (μM)

Without EGF

With EGF

Erlotinib

pBabe

6.1 ± 0.7

7.3 ± 1.2

7.95 ± 0.4

WT

7.7 ± 1.2

11.4 ± 2.2

11.97 ± 1.8

T790M

12.0 ± 1.2

14.2 ± 1.5

15.16 ± 1.3

L858R

16.0 ± 1.6

19.3 ± 0.8

0.07 ± 0

K757E

7.5 ± 1.8

11.3 ± 3.1

24.67 ± 2.1

N808S

10.0 ± 2.3

12.1 ± 2.8

13.26 ± 5.3

R831C

7.1 ± 1.5

10.8 ± 3.2

8.47 ± 0.5

V897A

10.6 ± 2.5

12.5 ± 2.9

19.78 ± 3.3

P937L

11.3 ± 2.1

12.0 ± 1.2

12.32 ± 4.2

T940A

9.8 ± 2.3

13.2 ± 3.9

5.58 ± 0.4

M947T

9.5 ± 2.2

11.5 ± 3.2

12.3 ± 1.2

  1. IC50 values for erlotinib in EGFR mutants were calculated by using the data from Fig. 3