Fig. 1

The Fanconi anemia pathway of DNA repair. a Repair of ICL in replicative phase starts with convergence of two replication forks surrounding the ICL site. b FANCM/FAAP24 complex recognizes the X shaped DNA structure and recruits other members of the FA core complex and FAAPs. Monoubiquitination of the ID2 complex represents the step of activation of the FA pathway. c ID2 recruits FAN1 and structure specific nucleases for incision surrounding the ICL sites to unhook the damage. d Translesion synthesis polymerases REV1/pol ζ bypass the unhooked ICL damage. The unhooked ICL remnant will be subsequently repaired by NER. e Double strand break intermediates can be repaired via four sub-pathways of DNA DSB repair depending on the result of end resection