Fig.5
From: Alternative splicing signatures in preimplantation embryo development
Alternative splicing is linked to the TAD boundaries. a Example of Smc4 isoforms at the TAD boundaries (top: blue represents A compartment, orange represents B compartment; middle: heatmap of normalized Hi-C data, TAD boundary region, and DI values; bottom: the expression of Smc4 isoforms in zygotes and at the two-cell stage). b Circos plot shows that the AS genes were particularly associated with the TAD boundaries. (the circles from outside to inside sequentially represent the A/B compartments, gene density (green), TAD boundaries (red), and IS scores (gray color); the links represent the protein network for different types of AS genes.)