Table 2 The therapeutic effects of quercetin on ovarian cancer

Graphene oxide polyvinylpyrrolidone-Quercetin-gefitinib (GO-PVP-QSR-GEF)

Cocktailed drug system GO-PVP-QSR-GEF has more cytotoxicity than individual and free drugs toward PA-1 ovarian cancer cells compared to IOSE-364 somatic ovarian epithelial cells

10 mg/l

In vitro

[98]

Quercetin

Represses cell growth and induce apoptosis via reducing Bcl-2, Bcl-xL and increasing the expression level of caspase-3, caspase-9, cyto- c, Bid, Bad, and Bax in PA-1cell line

75 μM

In vitro

[99]

Quercetin

Regulate proliferation, apoptosis, and steroid and peptide hormone secretions in ovarian cells via decreasing PCNA and increasing BAX and in pigs cells T production and also IGF-I secreting reduced but in cattle cells, T releasing increased and at the lower concentration (1 or 10 ng/mL) and a high concentration (100 ng/mL), IGF-I releasing promoted and reduced, respectively

1 ng/mL, 10 ng/mL, 100 ng/mL

In vitro, in vivo

[139]

Micellar(nanostructures) resveratrol (R): Quercetin (Q) (mRQ)

Alleviates the ADR-induced cardiotoxicity

2.11 mg/ml

In vitro, in vivo

[140]

Quercetin

Regulates porcine ovarian granulosa cell roles in vitro via the pathway that may incorporate progesterone, cyclin B1 and p53

0.01 μmol/l, 0.1 μmol/l, 1 μmol/l, 10 μmol/l, 100 μmol/l

In vitro

[141]

Quercetin

Intensify tumor radiosensitivity via p53-mediated ER stress pathways

100 μmol/l

In vitro, in vivo

[102]

Quercetin

Combination treatment of Q1 with xylene shows restricted the effect of xylene on proliferation and IGF-I release, provoked the instigator operation of xylene on apoptosis, and increased the impact of xylene on the release of progesterone but not testosterone

1 μg/ml, 10 μg/ml, 100 μg/ml

In vitro

[20]

Quercetin

Provokes protective autophagy and apoptosis via ER stress by the p-STAT3/Bcl-2 axis in ovarian cancer

40 μM, 80 μM

In vitro, in vivo

[101]

Quercetin

Leads to repression of proliferation and the initiation of apoptosis in ovarian cancer SKOV-3 cells; but, the precise mechanism still needs more investigation

0.12 mg/ml, 0.23 mg/ml, 0.47 mg/ml, 0.94 mg/ml, 1.88 mg/ml, 3.75 mg/ml, 7.5 mg/ml, 15 mg/ml, 30 mg/ml

In vitro