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Table 2 The therapeutic effects of quercetin on ovarian cancer

From: Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells

Type of quercetin Mechanism(s) and effect(s) Dose(s) Model Refs.
Graphene oxide polyvinylpyrrolidone-Quercetin-gefitinib (GO-PVP-QSR-GEF) Cocktailed drug system GO-PVP-QSR-GEF has more cytotoxicity than individual and free drugs toward PA-1 ovarian cancer cells compared to IOSE-364 somatic ovarian epithelial cells 10 mg/l In vitro [98]
Quercetin Represses cell growth and induce apoptosis via reducing Bcl-2, Bcl-xL and increasing the expression level of caspase-3, caspase-9, cyto- c, Bid, Bad, and Bax in PA-1cell line 75 μM In vitro [99]
Quercetin Regulate proliferation, apoptosis, and steroid and peptide hormone secretions in ovarian cells via decreasing PCNA and increasing BAX and in pigs cells T production and also IGF-I secreting reduced but in cattle cells, T releasing increased and at the lower concentration (1 or 10 ng/mL) and a high concentration (100 ng/mL), IGF-I releasing promoted and reduced, respectively 1 ng/mL, 10 ng/mL, 100 ng/mL In vitro, in vivo [139]
Micellar(nanostructures) resveratrol (R): Quercetin (Q) (mRQ) Alleviates the ADR-induced cardiotoxicity 2.11 mg/ml In vitro, in vivo [140]
Quercetin Regulates porcine ovarian granulosa cell roles in vitro via the pathway that may incorporate progesterone, cyclin B1 and p53 0.01 μmol/l, 0.1 μmol/l, 1 μmol/l, 10 μmol/l, 100 μmol/l In vitro [141]
Quercetin Intensify tumor radiosensitivity via p53-mediated ER stress pathways 100 μmol/l In vitro, in vivo [102]
Quercetin Combination treatment of Q1 with xylene shows restricted the effect of xylene on proliferation and IGF-I release, provoked the instigator operation of xylene on apoptosis, and increased the impact of xylene on the release of progesterone but not testosterone 1 μg/ml, 10 μg/ml, 100 μg/ml In vitro [20]
Quercetin Provokes protective autophagy and apoptosis via ER stress by the p-STAT3/Bcl-2 axis in ovarian cancer 40 μM, 80 μM In vitro, in vivo [101]
Quercetin Leads to repression of proliferation and the initiation of apoptosis in ovarian cancer SKOV-3 cells; but, the precise mechanism still needs more investigation 0.12 mg/ml, 0.23 mg/ml, 0.47 mg/ml, 0.94 mg/ml, 1.88 mg/ml, 3.75 mg/ml, 7.5 mg/ml, 15 mg/ml, 30 mg/ml In vitro