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Table 1 The therapeutic effects of quercetin on various cancers

From: Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells

Cancer Type of quercetin Mechanism(s) and Effect(s) Dose(s) Model Refs.
Gastric cancer (GC) Quercetin Antimetastatic effects on GC Cells via interruption of uPA/uPAR Function by Modulating NF-κb, PKC-δ, ERK1/2, and AMPKα 10 μM Human, in vitro [65]
Quercetin Suppresses the growth of human GC stem cells by provoking mitochondrial-dependent apoptosis by the repression of PI3K/Akt signaling 20 µM In vitro [120]
Q1 isolated from Polygonum capitatum (PC) Modulation of apoptosis rate of GC cells via controlling the levels of p38MAPK, BCL-2 and BAX genes 10 μg/mL, 64 μg/mL In vitro, in vivo [121]
Breast cancer (BC) Q1 targeted via phenyl boronic acid and zinc oxide nanoparticles (PBA-ZnO-Q) Induced apoptotic cell death in BC cells via intensified combinatorial ROS(oxidative stress and mitochondrial damage) 8 μg/mL, 10 mg/kg In vitro, in vivo [122]
Quercetin Induced the expressions of Bax and cleaved caspase-3 and represses the proliferation and invasion activities by overexpression of miR-146a 80 µm/mL In vitro, in vivo [123]
Quercetin Represses BC stem cells (CD44+/CD24−) by restraining the PI3K/Akt/mTOR-signaling pathway 50 μM In vitro, in vivo [13]
Colorectal cancer (CRC) Quercetin Promoted apoptosis in KRAS-mutant CRC cells via activation of JNK signaling pathways and repression of the AKT pathway 100 µM In vitro [17]
Quercetin Promote 5-fluorouracil-induced apoptosis in MSI CRC cells via p53 regulation 1 µM, 100 µM In vitro [124]
Quercetin Provokes cell cycle arrest and apoptosis in stem cells of human colorectal HT29 cancer cell line, improves anticancer effects of doxorubicin 75 µM In vitro [125]
Oral cancer Quercetin Represses cell viability, migration and invasion through modulating miR-16/HOXA10 axis 50 μM Human, in vitro [126]
Quercetin Enhanced apoptosis in human oral cancer SAS cells by mitochondria and endoplasmic reticulum-mediated signaling pathways 40 µM In vitro [127]
Quercetin Decreases tumor rate and provokes cancer-cell apoptosis via regulation of NF-κB signaling and its target genes Bcl-2 and Bax in the DMBA-induced hamster 12.5 mg/kg, 25 mg/kg, 50 mg/kg In vivo [128]
Liver cancer Gold-Q1 into poly(dl-lactide-co-glycolide) nanoparticles Suppress liver cancer progression via repressing AP-2β/hTERT, impeding caspase/cyto-c pathway, inactivating NF-κB/COX-2 and preventing Akt/ERK1/2 signaling pathways 30 µg/ml, 40 µg/ml, 50 µg/ml In vitro, in vivo [68]
Quercetin Have hepatoprotective activity versus bile duct ligation caused liver damage through decreasing of Rac1 and NADPH oxidase1 expression 30 mg/kg In vivo [129]
Quercetin Decrease migration and invasion of HCCLM3 Cells by impeding the expression of p-Akt1, MMP-2, and MMP-9 20 μmol, 40 μmol, 60 μmol In vitro [130]
Prostate cancer (PCa) Quercetin Represses PCa via attenuating cell survival and frustrating anti-apoptotic pathways 40 μM In vitro [69]
Quercetin Midkine decreasing lead to increases the effectiveness of Q1 on PCa stem cell survival and migration via PI3K/AKT and MAPK/ERK pathway 29 μM, 35 μM In vitro [131]
Quercetin Converts the doxorubicin resistance of PCa cells via targeting the c-met/PI3K/AKT pathway 10 μM In vitro [132]
Thyroid cancer Quercetin Decreases cell proliferation and promoted apoptosis through caspase activation and downregulation of Hsp90 expression 10 μM, 5 μM In vitro [59]
Quercetin Promotes activator protein1(AP1)activation in FRTL-5 thyroid cells 10 μM In vitro [73]
Hyaluronic acid hydrogel loaded with Q1 Anti-inflammatory action by evaluating IL-4, IL-10, IL-8, IL-1a, and TNFα cellular secretion 2.8 mg/ml, 4.2 mg/ml, 8.4 mg/ml In vitro [133]
Hematological malignancies Quercetin Enhances the effect of TRAIL-induced apoptosis in KG-1 cells, increased the expression level of DR genes including DR4 and DR5, reducing expression of p65 and c-IAP1, c-IAP2, and XIAP 100 µM In vitro [83]
Quercetin Provokes apoptosis, cell cycle, and autophagy by decreasing expression of anti-apoptotic proteins, BCL-2, BCL-XL and MCL-1 and increasing expression of BAX, activation of caspase-3, G1 phase cell cycle arrest and inducing conversion of LC3-I to LC3-II 120 mg/kg In vitro, in vivo [134]
Quercetin Promotes apoptosis and autophagy in primary effusion lymphoma cells via repressing PI3K/AKT/mTOR and STAT3 signaling pathways 50 μM In vitro [135]
Lung cancer Quercetin An antiproliferative and antimetastatic effect on A549 non-small cell lung cancer cells via the impact on the cytoskeleton 74 μM In vitro [136]
Quercetin Represses the metastatic capacity of lung cancer via suppressing, Snail-dependent Akt activation and Snail-independent ADAM9 expression pathways 10μM, 50 μM In vitro, in vivo [137]
Quercetin Promotes apoptosis in the lung cancer via modulation of p53 posttranslational modifications 100 mg/kg In vivo [138]
Pancreatic cancer Quercetin Induced miR-200b-3p expression and consequently lead to modulate the form of self-renewing divisions in pancreatic cancer 50 μM In vitro [70]
Quercetin Overexpression of microRNA let-7c and suppress pancreatic cancer progression via activation of Numbl 50 μM In vivo, in vitro [95]
Quercetin Promoted TRAIL-induced apoptosis through JNK activation-mediated cFLIP turnover 30 μM, 60 μM, 90 μM In vitro [96]