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Fig. 4 | Cell & Bioscience

Fig. 4

From: Murine hepatoblast-derived liver tumors resembling human combined hepatocellular-cholangiocarcinoma with stem cell features

Fig. 4

Both murine p53−/− hepatoblast-derived tumors and human cholangiohepatoma exhibit similar differentiation patterns. a Fields of double-immunofluorescence staining for EpCAM/AFP murine and human tumors are shown. In murine tumors (upper image), cells showing membrane and cytoplasmic EpCAM staining (purple) co-localizing with cytoplasmic AFP (green) are shown. In human tumors (lower image), similar cells showing weak cytoplasmic EpCAM staining (green) co-localizing with cytoplasmic AFP (red) appear to be orange in cytoplasm and green in membrane. b Images of double-immunofluorescence staining for CK19/ALB in murine tumors and CK19/AFP in human tumors are presented. Representative fields of intermediated area (left), cholangiocellular carcinoma (middle), and cholangiolocellular carcinoma (right) are shown. Tumor cells with intermediate phenotype appear to be yellow/orange

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