Fig. 1

Volcano-plots of differential expression of circRNAs for stroke etiology comparisons. Graphs visualize the relationship between fold-change (magnitude of change) in the X axes and statistical significance (which takes both magnitude of change and variability into consideration) in the Y axes. A high number of circRNAs are shown as differentially expressed between atherotrombotic versus cardioembolic strokes (a), and atherotrombotic versus undetermined strokes (b) whereas cardioembolic versus undetermined strokes show less differences suggesting both groups are similar in terms of circRNA expression. The vertical green lines correspond to the threshold of 1.5-fold up and down, respectively, and the horizontal green line represents a p-value = 0.05. Red points in the plot represent the differentially expressed circRNAs with statistical significance which crossed the fold-change threshold