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Table 1 The properties and characteristics of VGLUTs

From: Research progress on the role of type I vesicular glutamate transporter (VGLUT1) in nervous system diseases

 VGLUT1VGLUT2VGLUT3
Gene nameSLC7A7SLC7A6SLC7A8
Atomic mass (kDa)61.664.465
Number of amino acids560582589
C-and N-terminal domainsIntracellularIntracellularIntracellular
Number of transmembrane domains6–121210
Expression organ sitesBrainBrainSmall intestine/brain/colon
Highest expression organ(s)Anterior cingulate cortexLateral nuclear group of thalamusSmall intestine Peyer’s patch
FunctionsMediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate