Table 1 The properties and characteristics of VGLUTs
| Â | VGLUT1 | VGLUT2 | VGLUT3 |
|---|---|---|---|
Gene name | SLC7A7 | SLC7A6 | SLC7A8 |
Atomic mass (kDa) | 61.6 | 64.4 | 65 |
Number of amino acids | 560 | 582 | 589 |
C-and N-terminal domains | Intracellular | Intracellular | Intracellular |
Number of transmembrane domains | 6–12 | 12 | 10 |
Expression organ sites | Brain | Brain | Small intestine/brain/colon |
Highest expression organ(s) | Anterior cingulate cortex | Lateral nuclear group of thalamus | Small intestine Peyer’s patch |
Functions | Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate | ||