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Table 1 The properties and characteristics of VGLUTs

From: Research progress on the role of type I vesicular glutamate transporter (VGLUT1) in nervous system diseases

  VGLUT1 VGLUT2 VGLUT3
Gene name SLC7A7 SLC7A6 SLC7A8
Atomic mass (kDa) 61.6 64.4 65
Number of amino acids 560 582 589
C-and N-terminal domains Intracellular Intracellular Intracellular
Number of transmembrane domains 6–12 12 10
Expression organ sites Brain Brain Small intestine/brain/colon
Highest expression organ(s) Anterior cingulate cortex Lateral nuclear group of thalamus Small intestine Peyer’s patch
Functions Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate