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Fig. 6 | Cell & Bioscience

Fig. 6

From: Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway

Fig. 6

Dynorphin/KOR regulated microglial M2 polarization inhibited neuronal apoptosis. The conditioned medium of BV-2 cells in the groups of Control, LPS, LPS + Dynorphin-A, LPS + GNT1, and LPS + Dynorphin-A + GNT1 were collected and co-cultured with the primary mouse hippocampal neurons. a The neuronal viability was examined by CCK-8 assay. b The neuronal apoptosis was examined by flow cytometry with Annexin-V-FITC/PI dual-labeling. c The protein levels of apoptosis-related caspase-3, Bax, and Bcl-2 in the primary mouse hippocampal neurons were examined by western blot. *p < 0.05, **p < 0.01, vs. Control group, #p < 0.05, ##p < 0.01, vs. LPS group; &p < 0.05, &&p < 0.01, vs. LPS + Dyn-A group

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Cell & Bioscience

ISSN: 2045-3701

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