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Fig. 4 | Cell & Bioscience

Fig. 4

From: Insights into superoxide dismutase 3 in regulating biological and functional properties of mesenchymal stem cells

Fig. 4

The effect of SOD3 on MSCs. SOD3 found to increase the anti-inflammatory properties of MSCs through secretion of various immunosuppressive factors. MSCs over expressed with SOD3 exhibited increase survival rate than normal MSCs under starvation. MSCs over-expressed with SOD3 also exhibited enhanced therapeutic potential through modulation of various receptors, signaling pathways and cellular mechanisms. SOD3 superoxide dismutase 3, MSCs mesenchymal stem cells, AMPK AMP-activated protein kinase, SIRT1 sirtulin 1, FoxO3a Forkhead box O3a, ERK extracellular signal-regulated kinase, Akt protein kinase B, TLR-7 Toll-like receptor-7, NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells, JAK-STAT janus kinases- signal transducer and activator of transcription proteins, H4R histamine receptor 4

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