Fig. 1
From: RNA N6-methyladenosine: a promising molecular target in metabolic diseases
The dynamic and reversible processes of m6A methylation and its biological functions. m6A RNA modification is a widespread and reversible process which is catalyzed by “writers”, consisting of METTL3, METTL14, WTAP, HAKAI, ZC3H13/KIAA0853, VIRMA/KIAA1429, RBM15B and RBM15. Meanwhile, the m6A methylation can be removed by m6A “erasers”, including FTO and ALKBH5. Besides, it is recognized by “readers”-YTHDF1, YTHDF2, YTHDF3, YTHDC1, YTHDC2, IGF2BP1, IGF2BP2, IGF2BP3, FMRP and PRRC2A. The biological functions of m6A methylation on stability, translation, splicing or nuclear export are highly involved in m6A methylation associated diseases