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Fig. 5 | Cell & Bioscience

Fig. 5

From: The antagonism of 6-shogaol in high-glucose-activated NLRP3 inflammasome and consequent calcification of human artery smooth muscle cells

Fig. 5

6-Shogaol attenuates HG-triggered Akt activation, ROS production, and NLRP3 inflammasome in HASMCs. a, b HASMCs were kept as the controls or were pretreated with ethanol or 6-shagaol and then treated with HG for 4, 24, and 48 h. The Akt phosphorylation, ROS production, and NLRP3/IL-1β (pro and mature form) protein expressions in HASMCs were examined. Results in a and c are representative of three independent experiments with similar results and the bar graphs are mean ± SEM from three independent experiments. Data in b are mean ± SEM from three independent experiments. *P < 0.05 vs. control cells. #P < 0.05 vs. EtOH/HG-treated cells

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