Fig. 2From: The antagonism of 6-shogaol in high-glucose-activated NLRP3 inflammasome and consequent calcification of human artery smooth muscle cellsHG activates NLRP3 inflammasome to modulate HASMC calcification. HASMCs were kept as the controls or were treated with NG or HG for 12, 24, or 48 h or 14 days and then the mRNA a and protein b expressions of NLRP3, caspase 1 (pro and cleaved form), and IL-1β (pro and mature form), the mRNA expressions of OPN, OCN, and ALP c, and HASMC calcification d were examined. Data in a and c, d are mean ± SEM from three independent experiments. Results in b are representative of three independent experiments with similar results and the bar graphs are mean ± SEM from three independent experiments. *P < 0.05 vs. control cells. #P < 0.05 vs. DMSO/HG-treated cellsBack to article page