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Fig. 2 | Cell & Bioscience

Fig. 2

From: The antagonism of 6-shogaol in high-glucose-activated NLRP3 inflammasome and consequent calcification of human artery smooth muscle cells

Fig. 2

HG activates NLRP3 inflammasome to modulate HASMC calcification. HASMCs were kept as the controls or were treated with NG or HG for 12, 24, or 48 h or 14 days and then the mRNA a and protein b expressions of NLRP3, caspase 1 (pro and cleaved form), and IL-1β (pro and mature form), the mRNA expressions of OPN, OCN, and ALP c, and HASMC calcification d were examined. Data in a and c, d are mean ± SEM from three independent experiments. Results in b are representative of three independent experiments with similar results and the bar graphs are mean ± SEM from three independent experiments. *P < 0.05 vs. control cells. #P < 0.05 vs. DMSO/HG-treated cells

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