COX-2 inhibitor | Celecoxib | 3, 10, 50 mg/kg/day | Mice | No effect on fracture healing | [92, 93] |
10 mg/kg/day | Rat | No effect on fracture consolidation | [98] |
2, 3, 4, 6, 8 mg/kg/day | Rat | Inhibit fracture consolidation with all doses over time course | [95,96,97,98] |
1 mg/kg | Rat | No effect on fracture consolidation | [99] |
Acetic acid | Diclofenac | 1, 2 mg/kg/day | Rat | No effect on fracture healing | [100] |
Etodolac | 20 mg/kg/day | Rat | Inhibits fracture consolidation | [101] |
Indomethacin | 2 mg/kg/day | Rat | Inhibits bone remodeling | [101] |
Short-term | Rat | Inhibits fracture consolidation | [102] |
Propionic acid | Ibuprofen | 30 mg/kg/day | Mice | No effect on fracture healing | [103] |
30 mg/kg/day | Rat | No effect on fracture consolidation | [104] |
30 mg/kg/day | Rat | Inhibits fracture consolidation | [105] |
7.5, 17, 34 mg/kg/day | Rabbit | Inhibits fracture healing with dose response | [83] |
Naproxen | 4–28 mg/L | Rat | Inhibit osteoclastic activity and bone resorption | [106] |
100 mg/L | Rat | Prevents transient loss of bone mass and structural deterioration | [107] |
10 mg/kg/day | Rat | No effect on BMD and biomechanical properties of spine and femur | [108] |