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Table 1 Animal studies regarding the functions of NSAIDs in bone remodeling and fracture healing

From: Dose-dependent roles of aspirin and other non-steroidal anti-inflammatory drugs in abnormal bone remodeling and skeletal regeneration

CategoryNSAIDsDosageModelFunctionRefs.
COX-2 inhibitorCelecoxib3, 10, 50 mg/kg/dayMiceNo effect on fracture healing[92, 93]
10 mg/kg/dayRatNo effect on fracture consolidation[98]
2, 3, 4, 6, 8 mg/kg/dayRatInhibit fracture consolidation with all doses over time course[95,96,97,98]
1 mg/kgRatNo effect on fracture consolidation[99]
Acetic acidDiclofenac1, 2 mg/kg/dayRatNo effect on fracture healing[100]
Etodolac20 mg/kg/dayRatInhibits fracture consolidation[101]
Indomethacin2 mg/kg/dayRatInhibits bone remodeling[101]
Short-termRatInhibits fracture consolidation[102]
Propionic acidIbuprofen30 mg/kg/dayMiceNo effect on fracture healing[103]
30 mg/kg/dayRatNo effect on fracture consolidation[104]
30 mg/kg/dayRatInhibits fracture consolidation[105]
7.5, 17, 34 mg/kg/dayRabbitInhibits fracture healing with dose response[83]
Naproxen4–28 mg/LRatInhibit osteoclastic activity and bone resorption[106]
100 mg/LRatPrevents transient loss of bone mass and structural deterioration[107]
10 mg/kg/dayRatNo effect on BMD and biomechanical properties of spine and femur[108]
  1. NSAIDs nonsteroidal anti-inflammatory drugs, BMD bone mineral density
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