Category | NSAIDs | Dosage | Model | Function | Refs. |
---|---|---|---|---|---|
COX-2 inhibitor | Celecoxib | 3, 10, 50Â mg/kg/day | Mice | No effect on fracture healing | |
10Â mg/kg/day | Rat | No effect on fracture consolidation | [98] | ||
2, 3, 4, 6, 8Â mg/kg/day | Rat | Inhibit fracture consolidation with all doses over time course | |||
1Â mg/kg | Rat | No effect on fracture consolidation | [99] | ||
Acetic acid | Diclofenac | 1, 2Â mg/kg/day | Rat | No effect on fracture healing | [100] |
Etodolac | 20Â mg/kg/day | Rat | Inhibits fracture consolidation | [101] | |
Indomethacin | 2Â mg/kg/day | Rat | Inhibits bone remodeling | [101] | |
Short-term | Rat | Inhibits fracture consolidation | [102] | ||
Propionic acid | Ibuprofen | 30Â mg/kg/day | Mice | No effect on fracture healing | [103] |
30Â mg/kg/day | Rat | No effect on fracture consolidation | [104] | ||
30Â mg/kg/day | Rat | Inhibits fracture consolidation | [105] | ||
7.5, 17, 34Â mg/kg/day | Rabbit | Inhibits fracture healing with dose response | [83] | ||
Naproxen | 4–28 mg/L | Rat | Inhibit osteoclastic activity and bone resorption | [106] | |
100Â mg/L | Rat | Prevents transient loss of bone mass and structural deterioration | [107] | ||
10Â mg/kg/day | Rat | No effect on BMD and biomechanical properties of spine and femur | [108] |