Table 3 Experimental studies that investigated the role of piRNAs in lung cancer
From: Epigenetic roles of PIWI proteins and piRNAs in lung cancer
PiRNAs/PiR-Ls | Up/Down | Related pathway | Tissue/cell line | Final result | Ref |
|---|---|---|---|---|---|
PiR-651 | Up | Cyclin D1 and CDK4 pathway | HepG2/HeLa/Bcap-37/MSTO- 211H/NCI-H446/MGC-803/SGC-7901/95-D/NSCLC A549/HCC827/A549 cells | Increase in cancer progression and cell viability/promoting metastasis, invasion and migration/apoptosis reduction | |
PiR-55490 | Down | Akt/mTOR pathway | A549/H460/H1299/MRC-5 | Increase in cell proliferation and tumor progression | [51] |
PiR-34871 and piR-52200 | Up | AMPK pathway | A549/H1299 | Cell proliferation enhancing | [53] |
PiR-46545 and piR-35127 | Down | AMPK pathway | A549/H1299 | Cell proliferation enhancing | [53] |
PiR-L-163 | Down | No investigated | H157/H226/H596, SK-MES-1/H522/H1437/H1792/H1944/HBE2/HBE3/HBE4 | Increasing of cell growth, invasion, and migration | [55] |
PiR-L-138 | Up | piR-L-138/p60-MDM2 phosphorylation | CDDP-based chemotherapy treated LSCC cell lines/PDX LSCC models with a CDDP based regimen | Apoptosis inhibition | [56] |