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Table 2 Experimental studies that investigated the role of PIWI proteins in lung cancer

From: Epigenetic roles of PIWI proteins and piRNAs in lung cancer

PIWIUp/DownTissue/cell lineTechniqueFinal resultRef
PIWIL1UpH23 and A549 cell linesReal-time PCR/immunohistochemistry/ELISA assayDecrease in survival time of patients and shorten time to relapse[27]
PIWIL4DownH23 and A549 cell linesReal-time PCR/immunohistochemistry/ELISA assayIncrease of transposon activities and genomic instability/decrease in survival time of patients and shorten time to relapse[27]
PIWIL2UpA549 and H460 cell lines/nude miceReal-time PCR/western blot/immunofluorescence staining/immunohistochemistry/flow cytometryProliferation induction/tumor growth promoting/apoptosis inhibition[36]
HIWIUpSSClo Aldebr cells/SPC-A1 cell line/miceHiwi shRNA plasmids treatment/immunohistochemistry/enzyme immunoassay/flow cytometryIncreasing proliferation/apoptosis reduction[28, 37]
HIWIUpA549 cell linesReal-time PCR/western blot/gain of function and loss of function strategies/colony formation assay/cell counting assayCell proliferation increasing[38]
PIWIL1UpA549 and H1299 cell linesReal-time PCR/gain of function and loss of function strategies/western blot/bioinformatics analysisEnhancing proliferation, migration and invasion[39]
PIWIL1UpA549/NCIH1299/CRL-
9482
Microarray analysis/real-time PCR/western blotIncrease in cell growth and proliferation[40]