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Fig. 2 | Cell & Bioscience

Fig. 2

From: DNA–protein cross-link repair: what do we know now?

Fig. 2

DPCs are composed of DNA, protein, and their cross-linked bonds, which can be targeted by different repair pathways. NER and HR are nuclease-dependent pathways that can directly cleave DNA molecules. The chemical bond between TOP1/TOP2 and DNA can be directly hydrolyzed by TDP1 and TDP2/ZNF451. Also, proteasomes, SPRTN/Wss1, and ACRC/GCNA-1 are related to proteolysis-dependent removal of covalently bound proteins

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