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Fig. 3 | Cell & Bioscience

Fig. 3

From: PRC1 promotes GLI1-dependent osteopontin expression in association with the Wnt/β-catenin signaling pathway and aggravates liver fibrosis

Fig. 3

Knockdown of PRC1 suppressed cell proliferation and promoted cell apoptosis of activated HSCs. a Transfection efficiency of shPRC1 #1/#2 or pcDNA3.1-PRC1 in activated HSCs. **Represents shPRC1 #1 or #2 vs. shNC; pcDNA3.1-PRC1 (PRC1) vs. pcDNA3.1 (vector) p < 0.01. b The effects of shPRC1 or pcDNA3.1-PRC1 on cell viability of activated HSCs. **Represents shPRC1 vs. shNC; PRC1 vs. vector, p < 0.01. c The effects of shPRC1 or pcDNA3.1-PRC1 on proteins expression of Bcl-2, Bax, Cleaved Caspase-3, caspase-3, PARP, Cleaved PARP, cyto cytochrome C and mito cytochrome C in activated HSCs. **Represents shPRC1 vs. shNC, p < 0.01. ##Represents PRC1 vs. vector, p < 0.01

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Cell & Bioscience

ISSN: 2045-3701

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