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Table 1 Comparative molecular properties of non-muscle myosin (NMII) and muscle myosin (MII)

From: TGF-β in fibrosis by acting as a conductor for contractile properties of myofibroblasts

 PlacentaTracheaSoleusEDLHeart
π2.1 (0.3)1.9 (0.1)2.3 (0.1)2.1 (0.1)1.6 (0.1)
f10.07 (0.05)8.9 (2.4)38 (11)242 (54)306 (89)
g20.33 (0.24)33.5 (8.4)328 (99)1162 (199)730 (15)
ATPase activity4.8 (0.1)2.9 (1.1)5 (2)50 (22)283 (177)
  1. Four main parameters of crossbridge (CB) myosin molecular motors are presented. CB unitary force (π; in pN); constant of CB attachment (f1; in s−1); constant of CB detachment (g2; in s−1); maximum ATPase activity (in nM g−1 s−1). Values ± SD were determined in human placenta [40], and in rat trachea, soleus, EDL and heart [50]. CB kinetics were dramatically low in non-muscle placental myofibroblasts compared with values reported in myocytes of trachea, soleus, EDL and heart. Only, CB unitary force was of same order of magnitude in both myofibroblasts and muscle cells