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Table 2 Small molecule inhibitors of the signaling pathways and their target genes (5)

From: Signaling pathways involved in colorectal cancer progression

Signaling pathwaysFactors/drugs approved (or) in developmentFunctionTarget
EGFR–RAS–MAPKCetuximabEGFR inhibitorEGFR
PanitumumabEGFR inhibitorEGFR
GefitinibEGFR inhibitorEGFR
SorafenibTyrosine kinase inhibitorRAF
PertuzumabMonoclonal antibody for Her 2Her2
ErlotinibReceptor tyrosine kinase inhibitorEGFR
Canertinib (CI-1033)Irreversible tyrosine kinase inhibitorEGFR
Her2
ErbB-4
LapatinibTyrosine kinase inhibitorEGFR
Her2
DacomitinibIrreversible EGFR inhibitorEGFR
SunitinibReceptor tyrosine kinase inhibitorRTKs
PD158780Tyrosine kinase inhibitorEGFR
ErbB-3
ErbB-4
Matuzumab (EMD72000)Monoclonal antibody for EGFREGFR
Vemurafenib (PLX4032)BRAFV600E inhibitorBRAFV600E
Dabrafenib (GSK2118436)BRAFV600E inhibitorBRAFV600E C-RAF
BRAF
Encorafenib (LGX818)RAF inhibitorBRAFV600E
XL281(BMS-908662)RAF kinases inhibitorRAF
Trametinib (GSK1120212)MEK1/2 inhibitorMEK1/2
BinimetinibMEK1/2 inhibitorMEK1/2
Selumetinib (AZD6244)MEK inhibitorMEK1/2
VX-11eERK2 inhibitorERK2
SCH772984ERK1/2 inhibitorERK1/2
NOTCHRO4929097γ Secretase inhibitorγ Secretase
DAPT (GSI-IX)γ Secretase inhibitorγ Secretase
Dibenzazepine (DBZ)γ Secretase inhibitorγ Secretase
LY411575γ Secretase inhibitorγ Secretase
GSI34γ Secretase inhibitorγ Secretase
PI3K–Akt–mTOROSI027mTOR kinase inhibitormTOR
PI3Kγ
MK2206AKT inhibitorAKT
GSK690693AKT inhibitorAKT
Everolimus (RAD001)mTOR inhibitormTOR
Idelalisib (CAL-101)P110 inhibitorP110γ/δ
BGT226PI3K/mTOR inhibitormTOR
PI3Kα/β/γ
Buparlisib
(BKM120)
PI3K inhibitorP110α/β/γ
Dactolisib (NVP-BEZ235)PI3K and mTOR inhibitormTOR
P110α/γδ
GSK690693Akt inhibitorAKT
AZD8055mTOR inhibitormTOR
Alpelisib (BYL719)PI3Kα inhibitorPI3Kα
PerifosineAkt inhibitorAKT
SF-1126Inhibitors of the PI3K pathwayPI3K
mTOR
Pilaralisib (XL147)PI3K inhibitorPI3Kα/β/γ/δ
Triciribine (VQD002)Akt inhibitorAKT
TemsirolimusKinase InhibitormTOR
TGF-βLY2109761TGF-β receptor inhibitorTGFBRI/II
AP15012Antisense moleculesTGF-β1
AP11014Antisense moleculesTGF-β
Wnt/β-cateninBC2059β-catenin inhibitorβ-catenin
SulindacBlocking the PDZ domain of the protein DishevelledDishevelled
PNU-74654Wnt/B-catenin inhibitorWnt/B-catenin