Autologous mitochondrial microinjection; a strategy to improve the oocyte quality and subsequent reproductive outcome during aging

Table 1 Summary of mitochondrial and/or ooplasmic transfer studies in the reproductive system

Species	Ooplasm or mitochondria transfer	Increased fertilization rate	Embryo development	Improved blastocysts rate	Clinical pregnancy	References
Human	Ooplasm	√	√	–	One baby	[53]
	Ooplasm	√	√	√	5 baby	[71]
	Ooplasm	√	√	–	Twin	[73]
	Oocyte mitochondria	√	√	√	–	[70]
	Ooplasm	√	√	–	Twin	[54]
	cGCs-mitochondria	√	√	√	7 twins 2 ectopic pregnancies	[65]
Mouse	Ooplasm	√	√	√	–	[79]
	Mitochondria	√	√	√	–	[80]
	Mitochondria	√	√	√	–	[26]
	Somatic cyto/mito	–	×	√	–	[81]
	Hepatocytes mitochondria	√	√	√	–	[22]
	ADSC-mitochondria	√	√	√	–	[8]
	Ooplasm	√	√	√	√	[11]
	Mitochondria	√	√	√	–	[82]
Cow	Granulosa cells mitochondria	√	√	√	–	[33]
Cow	Ooplasm	√	√	√	–	[28]
Pig	Mitochondria	√	√	√	–	[30]
Pig	Mitochondria	√	√	√	–	[40]
Hamster	Platelet mitochondria	√	√	√	–	[41]
Rabbit	Ooplasm	×	×	×	×	[74]

ISSN: 2045-3701