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Table 4 MiRNAs and their downregulated mRNA targets in the blood–brain barrier clearance of Aβ

From: Potential microRNA-related targets in clearance pathways of amyloid-β: novel therapeutic approach for the treatment of Alzheimer’s disease

MiRNA

Family

Gene

References

miR-185, miR-328-5p

Receptor for advanced glycation end products

RAGE

[220, 221]

miR-205

Low-density lipoprotein receptors

LRP1

[222]

miR-148b

 

LRP2

[223]

miR-26, miR-19b, miR-302a

ATP-binding cassette transporters

ABCA1

[224,225,226]

miR-200c, miR-873, miR-491-3p, miR-223

 

ABCB1

[227,228,229,230]

miR-328, miR-302, miR-3163, miR-181a

 

ABCG2

[231,232,233,234]

miR-185-5p, miR-463-3p

 

ABCG4

[235, 236]

miR-29b, miR-130b

Glymphatic clearance

AQP4

[237, 238]