Potential microRNA-related targets in clearance pathways of amyloid-β: novel therapeutic approach for the treatment of Alzheimer’s disease

Table 1 MiRNAs and their downregulated mRNA targets in UPS

MiRNAs	Family	Gene	References
miR-199a-5p	Ubiquitin-conjugating (E2) enzymes	UBE2G1	[45]
miR-101		UBE2N	[46]
miR-182, miR-145, miR-19a/b	Ubiquitin E3 ligases	CUL5	[47,48,49]
miR-195		CBX4	[50]
miR-221		HECTD2	[51]
miR-153		HECTD3	[52]
miR-542-5p		HUWE1	[53]
miR-106b, miR-411		ITCH	[54, 55]
miR-93		NEDD4L	[56]
miR-137		PIAS2	[57]
miR-199a-5p, miR-301a-3p, miR-9718, miR-21, miR-18a		PIAS3	[58,59,60,61,62]
miR-194		RBX1	[63]
miR-503, miR-542-5p, miR-497, miR-15b		SMURF1	[64,65,66,67]
miR-486, miR-424, miR-322, miR-503, miR-15a/b, miR-16, miR-128		SMURF2	[68,69,70,71]
miR-542-3p		UBE3C	[72]
miR-584-5p, miR-21		WWP1	[73, 74]
miR-214		RNF8	[75]
miR-19b		MYLIP	[76]
miR-214		RFWD2	[77]
miR-31	Deubiquitinating enzymes	BAP1	[78]
miR-17		USP2	[79]
miR-148a		USP4	[80]
miR-205		USP7	[81]
miR-135b		USP13	[82]
miR-320a		USP14	[83]
miR-34b		USP22	[84]
miR-200c		USP25	[85]
miR-363-3p		USP28	[86]
miR-204-5p		USP47	[87]
miR-25		Ataxin-3	[88]
miR-125b-5p		A20	[89]
miR-24		CSN5	[90]

ISSN: 2045-3701