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Fig. 5 | Cell & Bioscience

Fig. 5

From: Potential microRNA-related targets in clearance pathways of amyloid-β: novel therapeutic approach for the treatment of Alzheimer’s disease

Fig. 5

Receptor-mediated Aβ phagocytosis. The immune microglial cells and astrocytes reduce the load of Aβ in the brain by phagocytosis mediated by surface receptors. Aβ is directly phagocytosed by toll-like receptors and scavenger receptors, while the presence of LDL is crucial for TREM2-dependent phagocytosis. TLR2 toll like receptor 2, TLR4 toll like receptor 4, TLR9 toll like receptor 9, TREM2 triggering receptor expressed on myeloid cells 2, LDL low density lipoprotein, SR-A scavenger receptor class A, SR-B1 scavenger receptor class B type 1

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