Fig. 4

MiRNA-dependent regulation of Aβ clearance through the BBB. Aβ efflux and influx through the BBB. Aβ entrance to the brain is mediated by RAGE, but several transporters are expressed on both the luminal and abluminal sides of the BBB can eliminate Aβ from the brain. LRP1 is one of the major receptors for Aβ efflux through the BBB. Due to the sink hypothesis, it is also implicated in Aβ removal. Presence of Clusterin is essential for Aβ clearance by LRP2 receptor. ABCA1 indirectly facilitates Aβ clearance by lipidating ApoE. The drug pumps ABCB1 and ABCG2 are also involved in Aβ transport across the BBB. RAGE receptor for advanced glycation end products, LRP1 LDL receptor related protein 1, LRP2 LDL receptor related protein 2, ABCA1 ATP binding cassette subfamily A member 1, ABCB1 multidrug resistance protein, P-glycoprotein, ABCG2 breast cancer resistance protein, ABCG4 ATP binding cassette subfamily G member 4