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Fig. 6 | Cell & Bioscience

Fig. 6

From: Long noncoding RNA CASC2 suppresses esophageal squamous cell carcinoma progression by increasing SOCS1 expression

Fig. 6

CASC2 upregulates SOCS1 by competitively binding miR-155. a KYSE30 and KYSE150 cells were transfected with miR-155 mimics and the expression of SOCS1 mRNA was detected by real-time PCR. b KYSE30 and KYSE150 cells were transfected with miR-155 inhibitor and the expression of SOCS1 mRNA was detected by real-time PCR. c miR-155 mimics abolished the upregulation of SOCS1 expression mediated by CASC2 overexpression. d miR-155 inhibitor abolished the downregulation of SOCS1 expression mediated by CASC2 knockdown. e Luciferase activity in CASC2 overexprsessing KYSE30 and KYSE150 cells co-transfected with miR-155 mimics and luciferase reporters containing SOCS1 3′UTR. f Luciferase activity in CASC2 silencing KYSE30 and KYSE150 cells co-transfected with miR-155 inhibitor and luciferase reporters containing SOCS1 3′UTR. Error bars indicate SD. *p < 0.05

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