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Fig. 4 | Cell & Bioscience

Fig. 4

From: Preclinical development of HQP1351, a multikinase inhibitor targeting a broad spectrum of mutant KIT kinases, for the treatment of imatinib-resistant gastrointestinal stromal tumors

Fig. 4

HQP1351 exhibits antitumor activity in GIST xenograft models in vivo. Growth curves of subcutaneous xenografts of GIST T1 cells (a), weight of subcutaneous xenografts of GIST T1 cells at the end of the experiment (b), and body weight of Balb/c nu/nu mice bearing GIST T1 xenograft tumors (c) after treatment with HQP1351 and ponatinib. Growth curves of subcutaneous xenografts of GIST 430 cells (d), weight of subcutaneous xenografts of GIST 430 cells at the end of the experiment (e), and body weight of SCID Beige mice bearing GIST 430 xenograft tumors (f) after treatment with HQP1351 and ponatinib. *P < 0.05 vs. control; **P < 0.01 vs. control

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