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Table 1 Tissue-resident innate immune cells in common organ sites of metastasis

From: Suppressing immunotherapy by organ-specific tumor microenvironments: what is in the brain?

Metastasis target organ Innate immune cell type Function and contribution
Bone Osteoclasts Multinucleated cells transformed from monocytes that breaks down and absorbs the bone tissue, critical in the bone homeostasis
Brain Microglia Myeloid lineage glial cells accounting for 10-15% of all cells in the brain, mediating immune surveillance and inflammation in homeostasis and diseases of the central nervous system
Liver Kupffer cells Specialized macrophages lining the walls of the liver sinusoids, serving as the primary clearing cell for critical metabolic and detoxification functions of the liver
Lung Alveolar macrophages High activity macrophages located in pulmonary alveoli, the terminal units of gaseous exchange, primarily responsible for removing respiratory dust and pathogens
Omentum Peritoneal macrophages Omental milky spot-located macrophage cells playing house-keeping roles in immune surveillance, cell debris clearance and resolution of local inflammation