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Fig. 3 | Cell & Bioscience

Fig. 3

From: Angiotensin II receptor blocker LCZ696 attenuates cardiac remodeling through the inhibition of the ERK signaling pathway in mice with pregnancy-associated cardiomyopathy

Fig. 3

LCZ696 impedes Ang II-induced apoptosis of cardiomyocytes. Extracted cardiomyocytes were treated with Ang II (100 nM) alone or with LCZ696 (1.0 μM), or without any treatment. a Apoptosis of cardiomyocytes treated with LCZ696 in vitro detected by TUNEL staining (scale bar = 25 μm). b Quantitative analysis for AI of cardiomyocytes. c Western blot analysis of caspase 3 and cleaved-caspase 3 proteins in cardiomyocytes treated with LCZ696 or Ang II. *p < 0.05 vs. cardiomyocytes without treatment; #p < 0.05 vs. cardiomyocytes treated with Ang II. Measurement data (mean ± S.D.) among multiple groups was analyzed by one-way ANOVA, followed by Tukey post hoc test. The experiment was conducted 3 times independently

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