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Fig. 6 | Cell & Bioscience

Fig. 6

From: LncRNA H19 over-expression inhibited Th17 cell differentiation to relieve endometriosis through miR-342-3p/IER3 pathway

Fig. 6

LncRNA H19 over-expression inhibited the ectopic growth in the nude mouse endometriosis model. The nude mouse endometriosis model was established. CD4+ T cells were transfected with LncRNA H19 over-expression lentiviral vectors and induced Th17 polarizing, then intraperitoneally injected into the nude mouse endometriosis model. Nude mice were divided into EMS, EMS + Th17, EMS + lenti-Th17, EMS + lenti-H19-Th17 groups, with six mice in each group. a The weight of endometriosis-like lesions from nude mouse endometriosis model was increased in EMS + Th17 group, and H19 over-expression reversed the promotion effect of EMS + Th17. b Peritoneal fluid (PF) was collected to detect H19 and miR-342-3p expressions. LncRNA H19 was down-regulated in PF of EMS + Th17 group, and H19 over-expression reversed the inhibition effect of EMS + Th17. miR-342-3p was up-regulated in PF of EMS + Th17 group, and H19 over-expression reversed the promotion effect of EMS + Th17. c IER3 was down-regulated in PF of EMS + Th17 group, and H19 over-expression reversed the inhibition effect of EMS + Th17. *p < 0.05, compared with EMS; #p < 0.05, compared with EMS + lenti-NC + Th17

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