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Table 1 Activated FX generation (FXaG) parameters of the the 4-PBA treated rFVII-160R variant and of rFVIIwt, with (+) and without TFPI inhibition

From: The effect of the chemical chaperone 4-phenylbutyrate on secretion and activity of the p.Q160R missense variant of coagulation factor FVII

Anti-TFPI aptamer rFVII-160R 50 ng/ml rFVIIwt 10 ng/ml rFVIIwt 5 ng/ml
  +   +a   +a
Lag time (s) 348 ± 97 261 ± 64 205.3 ± 0.1 176 419.4 ± 9.5 354
TTP (s) 719 ± 96 605 ± 51 485.0 ± 0.1 445 778.1 ± 14.4 687
Peak (Rfu/s) 15.0 ± 3.0 19.8 ± 2.0 18.3 ± 0.3 23.0 10.8 ± 0.1 15.0
AUC (Rfu) 3127 ± 172 3496 ± 111 3388 ± 110 3694 3058 ± 37 3401
  1. TTP time to peak, RFU relative fluorescence units, AUC area under the curve
  2. aValues reported for rFVIIwt with anti-TFPI addition have been obtained in a single experiment