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Table 1 Activated FX generation (FXaG) parameters of the the 4-PBA treated rFVII-160R variant and of rFVIIwt, with (+) and without TFPI inhibition

From: The effect of the chemical chaperone 4-phenylbutyrate on secretion and activity of the p.Q160R missense variant of coagulation factor FVII

Anti-TFPI aptamer

rFVII-160R

50 ng/ml

rFVIIwt

10 ng/ml

rFVIIwt

5 ng/ml

 

+

 

+a

 

+a

Lag time (s)

348 ± 97

261 ± 64

205.3 ± 0.1

176

419.4 ± 9.5

354

TTP (s)

719 ± 96

605 ± 51

485.0 ± 0.1

445

778.1 ± 14.4

687

Peak (Rfu/s)

15.0 ± 3.0

19.8 ± 2.0

18.3 ± 0.3

23.0

10.8 ± 0.1

15.0

AUC (Rfu)

3127 ± 172

3496 ± 111

3388 ± 110

3694

3058 ± 37

3401

  1. TTP time to peak, RFU relative fluorescence units, AUC area under the curve
  2. aValues reported for rFVIIwt with anti-TFPI addition have been obtained in a single experiment
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Cell & Bioscience

ISSN: 2045-3701

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