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Fig. 5 | Cell & Bioscience

Fig. 5

From: Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE−/− mice

Fig. 5

Metformin attenuates Ang-II-induced proliferation, apoptosis and autophagy in VSMCs. a EdU staining was used to detect the proliferation of VSMCs in five groups. b, c Flow cytometry was used to analyze the apoptosis and cell cycle of VSMCs. d Transmission electron micrographs demonstrate autophagosomes inside the cytoplasm of the VSMCs. e The expression of LC3B was detected by immunofluorescence

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