Fig. 5From: Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE−/− miceMetformin attenuates Ang-II-induced proliferation, apoptosis and autophagy in VSMCs. a EdU staining was used to detect the proliferation of VSMCs in five groups. b, c Flow cytometry was used to analyze the apoptosis and cell cycle of VSMCs. d Transmission electron micrographs demonstrate autophagosomes inside the cytoplasm of the VSMCs. e The expression of LC3B was detected by immunofluorescenceBack to article page