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Fig. 4 | Cell & Bioscience

Fig. 4

From: Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE−/− mice

Fig. 4

Metformin attenuates Ang-II-induced activation of PI3K/AKT/mTOR/autophagy pathway in ApoE/mice. a The mRNA levels of PI3K, AKT, mTOR, LC3B and Beclin1 in the aneurysmal wall tissue of abdominal aortic aneurysm (AAA) or the normal aortic tissue (Sham) were analyzed by qRT-PCR. b The protein levels of PI3K, AKT, mTOR, LC3B and Beclin1, and the phosphorylation levels of PI3K, AKT and mTOR were analyzed by Western blot

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