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Fig. 2 | Cell & Bioscience

Fig. 2

From: Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE−/− mice

Fig. 2

Metformin could attenuate the formation of Ang II-induced AAA in ApoE−/−mice. a Ultrasound was used to detect the maximum diameter of abdominal aorta in mice. b The abdominal aorta of mice in each group were removed surgically after 28 days of infusion and photographed. c The morphological changes of abdominal aorta in each group were observed using HE staining, EVG staining, Masson staining and Sirius Red Staining. d Tunel staining was used to detect the aortic tissue apoptosis. e Immunohistochemistry staining was used to observe the expression of CD31, CD68, MMP-2, and MMP-9 in aortic tissue

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