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Fig. 5 | Cell & Bioscience

Fig. 5

From: Steroid receptor coactivator 3 inhibits hepatitis B virus gene expression through activating Akt signaling to prevent HNF4α nuclear translocation

Fig. 5

A schematic diagram depicting the molecular mechanism by which SRC-3 inhibits HBV gene expression. SRC-3 inhibits HBV gene expression by activation of Akt signaling via inducing the expression of IGF1, IRS1, and IRS2 to prevent HNF4α nuclear translocation; HBV gene expression results in HBx protein production to stabilize SRC-3 protein, leading to a feedback inhibition of HBV gene expression

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