Fig. 5From: Steroid receptor coactivator 3 inhibits hepatitis B virus gene expression through activating Akt signaling to prevent HNF4α nuclear translocationA schematic diagram depicting the molecular mechanism by which SRC-3 inhibits HBV gene expression. SRC-3 inhibits HBV gene expression by activation of Akt signaling via inducing the expression of IGF1, IRS1, and IRS2 to prevent HNF4α nuclear translocation; HBV gene expression results in HBx protein production to stabilize SRC-3 protein, leading to a feedback inhibition of HBV gene expressionBack to article page