Fig. 3

SRC-3 inhibits HNF4α-induced HBV core-promoter activity. a Ectopic expression of SRC-3 or CA-Akt inhibited HNF4α-induced HBV core-promoter activity in HepG2 cells. b Transfection of CA-Akt into SRC-3-knockdown cells inhibited HBV core promoter activity. c Transfection of CA-Akt into SRC-3-knockdown cells prevented the nuclear translocation of HNF4α. Control constructs were transfected into control cell or SRC-3-knockdown cells and CA-Akt were transfected into SRC-3-knockdown cells for 48 h, then cell fractionation was carried out and fractions were analyzed by western blot. All experiments were repeated at least 3 times independently. *p < 0.05, **p < 0.01