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Table 3 Post-translational modification of PKM2 protein and its related biological effects

From: PKM2, function and expression and regulation

PTM (post-translational modification) effects of PKM2
Effects on modified protein Triggered by
 Enzymatic activity, induced K311-sc
 Enzymatic activity, inhibited Y105-p, Y148-p
 Enzymatic activity, regulation K186-Ub, K206-Ub
 Intracellular localization S37-p, S202-p, T405-gl, S406-gl
 Molecular association, regulation S37-p, Y105-p, S202-p, T405-gl, S406-gl
 Phosphorylation S37-p, T405-gl, S406-gl
 Protein conformation K311-sc, T405-gl, S406-gl
 Protein stabilization T328-p, T454-p
 Nuclear localization, regulation K305-Ac, K433-Ac
Effects on biological processes Triggered by
 Apoptosis, inhibited T328-p
 Apoptosis, induced C358-Ox, P403-OH, P408-OH
 Carcinogenesis, induced S37-p, T454-p
 Cell growth, induced S37-p, Y105-p, Y148-p, T328-p, T405-gl, S406-gl, T454-p
 Transcription, induced S37-p, T328-p
 Transcription, inhibited S37-p
Post-translational modification Specific Site
 Phosphorylation S37, Y105, Y148, S202, T454
 Acetylation K305, K433
 Hydroxylation and oxidation P403, P408 and K358
 Ubiquitination and sumoylation K186, K206
 Glycosylation T405, S406
 Methylation R445, R447, R455