Table 3 Post-translational modification of PKM2 protein and its related biological effects
PTM (post-translational modification) effects of PKM2 | |
|---|---|
Effects on modified protein | Triggered by |
 Enzymatic activity, induced | K311-sc |
 Enzymatic activity, inhibited | Y105-p, Y148-p |
 Enzymatic activity, regulation | K186-Ub, K206-Ub |
 Intracellular localization | S37-p, S202-p, T405-gl, S406-gl |
 Molecular association, regulation | S37-p, Y105-p, S202-p, T405-gl, S406-gl |
 Phosphorylation | S37-p, T405-gl, S406-gl |
 Protein conformation | K311-sc, T405-gl, S406-gl |
 Protein stabilization | T328-p, T454-p |
 Nuclear localization, regulation | K305-Ac, K433-Ac |
Effects on biological processes | Triggered by |
 Apoptosis, inhibited | T328-p |
 Apoptosis, induced | C358-Ox, P403-OH, P408-OH |
 Carcinogenesis, induced | S37-p, T454-p |
 Cell growth, induced | S37-p, Y105-p, Y148-p, T328-p, T405-gl, S406-gl, T454-p |
 Transcription, induced | S37-p, T328-p |
 Transcription, inhibited | S37-p |
Post-translational modification | Specific Site |
 Phosphorylation | S37, Y105, Y148, S202, T454 |
 Acetylation | K305, K433 |
 Hydroxylation and oxidation | P403, P408 and K358 |
 Ubiquitination and sumoylation | K186, K206 |
 Glycosylation | T405, S406 |
 Methylation | R445, R447, R455 |