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Fig. 7 | Cell & Bioscience

Fig. 7

From: Combination chemotherapy of valproic acid (VPA) and gemcitabine regulates STAT3/Bmi1 pathway to differentially potentiate the motility of pancreatic cancer cells

Fig. 7

Excessive ROS promotes p38 activation and suppresses the migration and invasion of pancreatic cancer cells. a PANC-1 and Patu8988 cells were pretreated with 10 μm of SB203580 for 2 h and then treated with 5 mM of VPA for 12 h, followed by cotreatment with gemcitabine for 24 h. The expression of Bmi1, p-p38 and p38 was detected by western blot analysis. b After pretreatment with 10 mM of NAC or 10 μm of SB203580 for 2 h, western blotting was performed to examine the changes in p-STAT3, STAT3, p-p38 and p38. c The migration and invasion were examined by Transwell assays after 10 μm SB203580 pretreatment for 2 h, followed by gemcitabine and 5 mM VPA cotreatment. *P < 0.05; **P < 0.01; ***P < 0.001 compared with the control

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